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Rheumatoid Arthritis - Role of M. tb 65 kDa hsp

"Antibody to Mycobacterium tuberculosis 65 kDa Heat Shock Protein in Patients with Rheumatoid Arthritis - A Survey of Antigen-Specific Antibody Isotypes and Subclasses in an Endemic Area of Previous T

Published in TB and Outbreaks Week, May 1st, 1995

According to the authors' abstract of an article published in Annals of the Rheumatic Diseases, "Objective: To clarify the significance of the humoral immune response triggered by the Mycobacterium tuberculosis (M. tb) 65 kDa heat shock protein (hsp) in the pathogenesis of rheumatoid arthritis (RA). Methods: M.tb 65 kDa hsp-specific IgG, IgA, IgM, and IgG subclass antibodies in serum or synovial fluid (SF) of RA and other disease patients were determined by enzyme linked immunosorbent assay (ELISA). Design: RA patients did not show any characteristic increase in mycobacterial 65 kDa hsp-specific antibodies compared with healthy individuals. In contrast,...

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