Therapy - Clofazimine
"Chemotherapeutic Activity of Clofazimine and Its Analogues Against Mycobacterium tuberculosis: In Vitro, Intracellular, and In Vivo Studies."
Published in TB and Outbreaks Week, May 22nd, 1995
According to the authors' abstract of an article published in American Journal of Respiratory and Critical Care Medicine, "Clofazimine (CFM), a riminophenazine drug, is primarily used in therapy for leprosy and Mycobacterium avium infections. With an objective of identifying drugs active against Mycobacterium tuberculosis, including those with multi-drug resistance, we investigated CFM and nine of its chemical analogues. Among these, B746 and B4101 had better activity than CFM against six drug-susceptible and nine single/multiple drug-resistant M. tuberculosis strains. B746 also showed slightly better activity than CFM against intracellular M. tuberculosis in...
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