Pathogenesis

Immune Response Linked to Increase in Growth Factors

Published in TB and Outbreaks Week, June 19th, 1995

Data from a human in vivo model of delayed type hypersensitivity (DTH) response indicate that the immune response is intimately associated with an increase in the production of growth factors and the initiation of a fibrotic response in tuberculosis patients.

The persistence of chronic inflammation is commonly associated with progression to tissue fibrosis and permanent organ damage. This is a special problem in the lungs, where it may occur in many interstitial lung diseases, sarcoidosis and untreated tuberculosis.

Pulmonary tuberculosis serves as a human disease model of chronic inflammation progressing to lung fibrosis, in which the pathogen and...

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Source: TB and Outbreaks Week (1995-06-19)

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