Therapy

Riminophenazines May Offer Treatment Options for TB

Published in TB and Outbreaks Week, July 10th, 1995

The riminophenazines are potential modulators of phagocyte function, suggesting that they may have a role in the treatment of tuberculosis.

Macrophages play a significant role in cell-mediated immune responses to mycobacterial infections. Through a series of evasive mechanisms mycobacteria effectively overcome destruction by host defenses. These include interference with the production of oxygen metabolites, inhibition of degranulation and phagosome-lysosome function, and an inference with macrophage activation.

"Because of such inhibitory effects of macrophages, it is conceivable that mycobacteria could negatively influence antigen presentation by...

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Source: TB and Outbreaks Week (1995-07-10)

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