Animal Models

Murine Model May Be Useful in Studying TB

Published in TB and Outbreaks Week, July 17th, 1995

A mouse model of latency and reactivation of Mycobacterium tuberculosis may offer the opportunity to study the role of T cells and macrophages during the course of disease, according to a report from Ohio State University.

Growth of mycobacterial species is controlled by the Bcg gene. Bcg acts at the macrophage level and is thought to control some aspect of macrophage priming for activation.

"Infection of Mycobacterium bovis BCG-susceptible (^Bcgs^{) mice with several different mycobacterial species results in the growth of the microorganisms, while the growth of the same organisms is controlled in...}

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Source: TB and Outbreaks Week (1995-07-17)

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