Animal Studies

Murine PBMC Engraftment May Enhance Search for New Vaccines

Published in TB and Outbreaks Week, July 17th, 1995

The engraftment of human peripheral blood mononuclear cells (PBMC) in normal mice and rats may have significant impact of the development of future vaccines, according to a report from Israel.

It has been reported that human peripheral blood mononuclear cells (PBMC) can be adoptively transferred intraperitoneally (IP) into the severe combined immune deficiency (SCID) mouse and that the engrafted cells survive for an extended period of time producing high levels of human Ig. This has offered many new possibilities in clinical immunology research, but major drawbacks to this approach include the impaired fuctionality of the engrafted human lymphocytes.

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Source: TB and Outbreaks Week (1995-07-17)

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