Therapy - Riminophenazines/Phagocyte Stimulants
"The Inhibitory Effects of Mycobacterium tuberculosis on MHC Class II Expression by Monocytes Activated with Riminophenazines and Phagocyte Stimulants."
Published in TB and Outbreaks Week, July 17th, 1995
According to the authors' abstract of an article published in Clinical and Experimental Immunology, "The expression of MHC class II antigens by peripheral blood monocytes from normal individuals was investigated. Class II expression as determined by a cell ELISA was effectively induced by various phagocyte stimulants. A further aspect of our study investigated the effects of clofazimine, a riminophenazine antimicrobial agent and its analogue, B669, on class II expression. Both agents at concentrations attainable in vivo increased the expression of MHC class II antigens. A 25-kD glycolipoprotein derived from Mycobacterium tuberculosis that inhibits phagocyte functions has...
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