Disease Markers

KL-6 Useful Marker for Fibroproductive Lesions

Published in TB and Outbreaks Week, August 7th, 1995

In tuberculosis, serum KL-6 originates from proliferated type II pneumocytes and cuboidal epithelial cells, and is a useful marker for pulmonary fibroproductive lesions, according to a report from Japan.

KL-6 is a mucin-like glycoprotein expressed on type II pneumocytes in alveoli and epithelial cells of bronchioles in the normal human lung, which consists of multiple heterogeneous molecules and is classified as 'Cluster 9 (MUC 1)' of lung tumor and differentiation antigens from the findings of immunohistochemical and flow-cytometry studies. KL-6 has been shown to be a valuable marker in sera and bronchoalveolar lavage fluids for the evaluation of disease activity of...

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Source: TB and Outbreaks Week (1995-08-07)

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