"Suppression of T-Cell Responses by TGF-(beta) in Tuberculosis."

According to an abstract submitted by the authors to the Clinical Research Meeting, held May 5-8, 1995, in San Diego, California, "Patients with tuberculosis have depressed T-cell blastogenesis and cytokine production in response to mycobacterial antigens. Transforming growth factor-(beta) (TGF-(beta)), a cytokine that suppresses T-cell responses and deactivates macrophage-effector functions is expressed in tuberculous granulomas in the lung, and is induced in monocytes (MN) by Mycobacterium tuberculosis (MTB) and its PPD. We examined the capacity of mycobacterial antigens to induce cytokine production and blastogenesis in 20 patients with pulmonary tuberculosis and matched...

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