Published in TB and Outbreaks Week, October 16th, 1995
It has long been believed that intraarticular complement activation plays a central role in the pathogenesis of rheumatoid arthritis. Activated B cells and plasma cells are present in inflamed synovium and in established disease.
Elevated levels of activated complement components, such as C3a, C5a and C5b-9 (membrane attack complex), have been found within inflamed rheumatoid joints, and positive correlations have been established between the degree of complement activation and the severity of joint...
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