"The Antimicrobial Activity of Novel Compounds (KOAs) Against Mycobacterium tuberculosis."

According to an abstract submitted by the authors to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, held September 17-20, 1995, in San Francisco, California, "The InhA gene encodes a common protein target for isoniazid and ethionamide action in Mycobacterium tuberculosis. The InhA protein catalyzes the NADH-specific reduction of 2-trans-enoyl-ACP, an essential step of fatty acid elongation. This enzyme preferentially reduces long chain substrates (12 to 24 carbons), which is consistent with its role in mycolic acid biosynthesis. We designed and synthesized a set of inhibitors based on the structure and function of InhA. These compounds (KOAs)...

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