Drug Resistance
"Predictors and Outcome of Multidrug-Resistant Tuberculosis."
Published in TB and Outbreaks Week, December 18th, 1995
According to the authors' abstract of an article published in Clinical Infectious Diseases, "We identify early predictors of multidrug-resistant tuberculosis and describe improved clinical outcomes, including survival, for patients with human immunodeficiency virus (HIV)-related multidrug-resistant tuberculosis (MDR-TB) when they are prospectively identified and receive treatment under direct observation. Analysis by means of a Cox proportional hazards model revealed that failure to defervesce while receiving a standard four-drug antituberculous regimen was independently associated with multidrug resistance (P=.004). When patients with HIV-related MDR-TB were prospectively...
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