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Epidemiologic RFLP Studies May Clarify TB Reinfection

Published in TB and Outbreaks Week, January 29th, 1996

Epidemiologic studies using restriction fragment length polymorphism (RFLP) analysis may shed light on the epidemiology of exogenous reinfection with Mycobacterium tuberculosis, according to a report from New York City's Stanford University Tuberculosis Control Bureau.

People with positive tuberculin skin tests are at lower risk of developing active tuberculosis following exposure to Mycobacterium tuberculosis than are tuberculosis negative persons, suggesting that previous M. tuberculosis infection confers some degree of acquired immunity.

The occurrence of exogenous reinfection with M. tuberculosis, however, indicates...

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