Immunology

Defective Antigen Processing Involved in Familial MAC

Published in TB and Outbreaks Week, March 11th, 1996

The primary immune defect in patients with familial disseminated mycobacterial infection rests in the antigen-processing functions of their antigen-presenting cells (APC), according to a report from California.

"These findings may provide clues to the wider problem of susceptibility to mycobacteria and other intracellular pathogens and have implications in designing therapy for these patients," researcher S. D'Souza and colleagues wrote ("Defective Antigen Processing Associated with Familial Disseminated Mycobacteriosis," Clinical and Experimental Immunology, January 1996;103(1):35-39).

D'Souza et al. recently reported a rare immunodeficiency in six...

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Source: TB and Outbreaks Week (1996-03-11)

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