Published in TB and Outbreaks Week, March 11th, 1996
The method is called expression library cloning. This involves systematically breaking down the genome of a pathogen into segments that can be manipulated until the most immunogenic epitopes are found.
"The problem with DNA vaccines is that, unlike live vaccines, the [immunogenic ] antigen must be defined," said researcher Stephen A. Johnston of the University of Texas Southwestern Medical Center,...
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