TB Vaccines

Auxotrophic BCG May Be Useful for At-Risk Populations

Published in TB and Outbreaks Week, May 6th, 1996

Auxotrophic strains of bacillus Calmette-Guerin (BCG) represent a potentially safe and useful vaccine against tuberculosis for populations with increased HIV risk, according to a report from New York's Albert Einstein College of Medicine.

The only currently available vaccine for tuberculosis, bacillus Calmette-Guerin (BCG), is the most widely used vaccine in the world. The safety of live attenuated BCG vaccine in HIV positive adults remains unknown, however, and is a matter of some concern.

Auxotrophic vaccine strains have been produced previously in virulent strains of Salmonella typhimurium, with mutations in galactose epimerase...

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Source: TB and Outbreaks Week (1996-05-06)

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