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Thiacetazone - Necessary Evil or Unjustifiable Killer?

Published in TB and Outbreaks Week, May 13th, 1996

Its use results in life-threatening skin reactions in up to one-third of HIV infected tuberculosis patients who are treated with it, but controversy persists regarding the use of thiacetazone in underdeveloped regions.

Is thiacetazone a necessary evil or an unethical alternative to more costly antituberculosis therapies' That thorny question continues to be debated by tuberculosis experts treating patients in poor, developing regions such as Kenya.

Researchers J. van Grokom and D.K. Kibuga of Nairobi, Kenya's National Leprosy Tuberculosis Program suggest that while greater education regarding the potentially life-threatening toxicity of thiacetazone...

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