Genetics

HLA Influences TB Susceptibility in Russian Province

Published in TB and Outbreaks Week, May 13th, 1996

HLA complex genetic factors were found to influence susceptibility to tuberculosis and other lung diseases in a study of children living in the Tuva Republic of Russia.

Products of HLA genes (HLA antigen) restrict T-cell recognition and immune response to several antigens of microbial origin and could thus play a significant role in genetic regulation of resistance to infection. Associations between tuberculosis and the HLA loci alleles have been demonstrated in several populations.

"Ethnic variability of associations between particular HLA class I antigens and tuberculosis interfere with our understanding of the mechanisms involved," researcher...

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Source: TB and Outbreaks Week (1996-05-13)

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