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Animal Models

Philippine Cynomolgus Monkey Superior for Study of TB

Published in TB and Outbreaks Week, June 3rd, 1996

The Philippine Cynomolgus monkey is an excellent model for chronic tuberculosis which allows the study of subclinical and potentially latent disease.

Old and New World monkeys are susceptible to tuberculosis, but studies of naturally acquired tuberculosis indicate that the degree of susceptibility varies among the different species. The rhesus monkey (Macaca mulatta) is highly susceptible to the disease. Even when challenged with low doses of Mycobacterium tuberculosis, the rhesus invariably develops an acute, fulminant, highly fatal form of tuberculosis.

"As the only established model of tuberculosis, the rhesus was used extensively...

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