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Disease Progression

Paradoxical Worsening of TB Effusions Not Uncommon

Published in TB and Outbreaks Week, June 3rd, 1996

Clinicians from Saudi Arabia's King Saud University report the paradoxical worsening of tuberculous effusions following the start of anti-tuberculosis treatment in 16 percent of their TB cases.

In many of the patients this response resulted in respiratory distress necessitating therapeutic re-aspiration.

Unusual expansion or new formation of tuberculous lesions during TB treatment has been referred to as a 'paradoxical response'. Paradoxical worsening of tuberculous lesions has been reported to occur weeks or months after the start of antituberculous therapy in the case of lymphadenopathy or intracranial tuberculoma (Chambers et al., Lancet...

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