Occupational Risk

Short Prophylaxis Not Effective in Gold Miners with Silicosis

Published in TB and Outbreaks Week, August 19th, 1996

A three-month chemoprophylaxis regimen involving rifampicin, isoniazid and pyrazinamide failed to adequately protect against tuberculosis in a group of gold miners with chronic silicosis.

People with silicosis, including chronic disease, have a greater risk of developing pulmonary tuberculosis than those without silicosis in the same population. The risk of developing TB also increases as silicosis advances.

Gold miners are at increased risk of developing silicosis.

"In this working population of gold miners (working in 24 South African gold mines) the average annual incidence of tuberculosis is 760 per 100,000," researcher R.L....

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Source: TB and Outbreaks Week (1996-08-19)

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