Bacteriology

M. tb Isoleucyl-tRNA Synthetase Cloned

Published in TB and Outbreaks Week, September 30th, 1996

The cloning and primary structure of Mycobacterium tuberculosis isoleucyl-tRNA synthetase has been reported by researchers from the Massachusetts Institute of Technology and the Japanese Foundation for Cancer Research.

The findings suggest that Mycobacterium tuberculosis isoleucyl-tRNA synthetase has an evolutionary history distinct from that of other eubacterial isoleucyl-tRNA synthetases.

Aminoacyl-tRNA synthetases play an essential role in all organisms by establishing the amino acid/trinucleotide algorithm of the genetic code through the aminoacylation of transfer RNAs. Due to their role in fixing the relationship between...

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Source: TB and Outbreaks Week (1996-09-30)

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