Diagnostics (Drug Resistance)
"Rapid Detection of Rifampin Resistance in Mycobacterium tuberculosis by a RNA/RNA Mismatch Assay."
Published in TB and Outbreaks Week, September 30th, 1996
According to an abstract submitted by the authors to the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, held September 15-18, 1996, in New Orleans, Louisiana, "Rifampin (RIF) and isoniazid remain the most effective antimicrobial agents available for treatment of tuberculosis and the rapid and sensitive detection of rifampin resistance (RIF-R) in M. tuberculosis (Mtb) has significant value for patient care and TB control. In addition, RIF-R is considered a surrogate marker for multiple drug resistant (MDR) Mtb. Over 95% of RIF-R Mtb is due to a mutation(s) within the RNA polymerase gene (rpo(beta) gene). Recently we described a rapid genetic...
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