Therapy (TB)

Protease Inhibitors Complicate TB Therapy

Published in TB and Outbreaks Week, December 9th, 1996

Interactions between HIV protease inhibitors and the anti-tuberculosis agent rifampin are complicating TB treatment in patients with AIDS. There is no clear solution to this problem, according to a report from the U.S. Centers for Disease Control and Prevention (CDC).

"Interrupting the administration of a protease inhibitor has the potential for inducing resistance to the drug and possibly to other agents in the protease inhibitor class of drugs, and also has a potential detrimental effect on a patient's clinical status," Elsa Villarino and Rick O'Brien of the CDC's Division of TB Elimination wrote in the winter issue of TB Notes ("The Use of HIV Protease Inhibitors...

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Source: TB and Outbreaks Week (1996-12-09)

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