Published in TB and Outbreaks Week, February 24th, 1997
The alveolar macrophage is the first line of defense in the lung against infection by M. tuberculosis. While resident inactivated alveolar macrophages phagocytose M. tuberculosis and generate signals for the induction of the cell-mediated immune response, they may be less effective at killing internalized microorganisms than macrophages which have been preactivated by lymphokines. After ingestion by macrophages, mycobacteria may persist and replicate as intracellular parasites, in part by...
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