Drug Resistance (TB)

Resistance Assessment For Rifampin/Isoniazid Simplified

Published in TB and Outbreaks Week, April 14th, 1997

Molecular detection of resistance to isoniazid and rifampin can be accomplished accurately by using a strategy which limits analysis to four genetic regions, according to a multicenter report.

Researcher A. Telenti and colleagues found the technique to be more than 90 percent sensitive in detecting resistance to the two most important tuberculosis drugs ("Genotypic Assessment of Isoniazid and Rifampin Resistance in Mycobacterium tuberculosis: a Blind Study at Reference Laboratory Level," Journal of Clinical Microbiology, March 1997;35(3):719723).

There have recently been advances in the understanding of the mechanisms of action of the...

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Source: TB and Outbreaks Week (1997-04-14)

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