Drug Development
"Analysis of the oxyR-ahpC Region in Isoniazid-Resistant and -Susceptible Mycobacterium tuberculosis Complex Organisms Recovered from Diseased Humans and Animals in Diverse Localities. DOUBLE
Published in TB and Outbreaks Week, April 21st, 1997
According to the authors' abstract of an article published in Antimicrobial Agents and Chemotherapy, "Automated DNA sequencing was used to analyze the oxyR-ahpC region in 229 Mycobacterium tuberculosis complex isolates recently recovered from diseased humans and animals. The entire 1,221-bp region was studied in 118 isolates, and 111 other isolates were sequenced for oxyR, ahpC, or the 105-bp oxyR-ahpC intergenic region. The sample included isoniazid (INH)-susceptible and -resistant organisms in which the katG gene and inhA locus had previously been sequenced in their entirety to identify polymorphisms. A total of 16 polymorphic sites was identified, including 5 located in oxyR,...
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