Published in TB and Outbreaks Week, April 21st, 1997
Researcher Beate Heym and colleagues found that Mycobacterium tuberculosis strains that produce catalase-peroxidase had a competitive advantage in immunocompetent hosts once the T-cell-mediated immune response, leading to the activation of macrophages and the release of large amounts of reactive O2 species, had been induced ("Effects of Overexpression of the Alkyl Hydroperoxidase Reductase AhpC on the Virulence and Isoniazid Resistance of Mycobacterium tuberculosis," Infection and Immunity,...
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