Immunology (TB)
"The Course of Mycobacterium tuberculosis Infection in the Lungs of Mice Lacking Expression of Either Perforin- or Granzyme-Mediated Cytolytic Mechanisms."
Published in TB and Outbreaks Week, May 19th, 1997
According to the authors' abstract of an article published in Infection and Immunity, "CD8 T cells have been shown to be protective against Mycobacterium tuberculosis infections in the mouse. These cells have been shown to be cytolytic toward M. tuberculosis-infected cells and have also been shown to release the protective cytokine gamma interferon in response to mycobacterial antigen. It has therefore been unclear how these cells mediate their protective response. To dissect this problem, we compared the courses of M. tuberculosis infections in control, perforin gene-knockout, and granzyme gene-knockout mice exposed by the realistic pulmonary route. The inability...
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