Published in TB and Outbreaks Week, May 19th, 1997
Researcher Christiane Abou-Zeid and colleagues found that the M. vaccae system is a convenient approach to the induction of type 1 responses to M. tuberculosis antigens.
T-cell-mediated immune responses can be categorized broadly as type I or II, based on the predominant cytokine profile expressed by the activated lymphocytes. A type I response is dominated by the production of gamma interferon (IFN-gamma), which triggers activation of macrophages, enhancing their microbicidal functions. A type II response is...
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