"MMAS-1, The Branch Point Between cis- and trans-Cyclopropane-Containing Oxygenated Mycolates in Mycobacterium tuberculosis."

According to the authors' abstract of an article published in Journal of Biological Chemistry, "The proportion of mycolic acid containing trans-substituents at the proximal position of the meromycolate chain is an important determinant of fluidity of the mycobacterial cell wall and is directly related to the sensitivity of mycobacterial species to hydrophobic antibiotics. MMAS-1, an enzyme encoded in the gene cluster responsible for the biosynthesis of methoxymycolates, was overexpressed in Mycobacterium tuberculosis and shown to result in the overproduction of trans-cyclopropane and trans-olefin-containing oxygenated mycolic acids. MMAS-1 converted a cis-olefin into a...

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