Coinfection (HIV/TB)

M. tuberculosis Infection Enhances HIV-1 Replication/Transmission

Published in TB and Outbreaks Week, June 30th, 1997

Mycobacterium tuberculosis infection appears to be able to up-regulate HIV-1 infection and replication within monocyte-derived macrophages, according to a multicenter report from Europe.

Researcher Giorgio Mancino and colleagues suggest that infection with M. tuberculosis increases the efficiency of HIV viral transmission from infected monocyte-derived macrophages (MDMs) to T cells ("Infection of Human Monocytes with Mycobacterium tuberculosis Enhances HIV-1 Replication and Transmission to T Cells," Journal of Infectious Diseases, June 1997;175:1531-1535).

Infection with and replication of HIV-1 are influenced by host factors and...

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Source: TB and Outbreaks Week (1997-06-30)

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