Published in TB and Outbreaks Week, August 4th, 1997
Recombinant adenoviruses (Ad) have been under development as gene transfer vehicles for the treatment of various lung diseases. Initial studies have demonstrated that recombinant Ad mediate high-efficiency gene transfer to airway epithelial cells in culture. Unfortunately, the efficiencies are markedly lower in primate and human conducting airway epithelium (J. Zabner et al., J. Clin. Invest. 1996;97:1504-11).
"This suggests the existence of barriers to adenovirus-mediated gene transfer to...
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