"Uptake of Mycobacterium tuberculosis into Pulmonary M Cells in a Mouse Respiratory Challenge Model."

According to an abstract submitted by authors to the Keystone Symposium Mucosal Immunity: Cellular and Molecular Cross-Talk at Mucosal Surfaces, held March 23-28, 1997, in Santa Fe, New Mexico, "Mycobacterium tuberculosis (TB), the etiologic agent of tuberculosis, is a respiratory pathogen responsible for more deaths each year than any other single pathogen. The airborne bacilli, carried in droplet nuclei, are thought to access the lung through their phagocytosis by resident alveolar macrophages. The currently held view is therefore that the initial host immune response to the pathogen is at the level of the alveolus, with the principal mediator of that response being the...

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