Published in TB and Outbreaks Week, October 27th, 1997
The finding could have significant implications for the development of new tuberculosis drugs and vaccines.
"The tool we have developed should greatly contribute to the genetic analysis of M. tuberculosis pathogenicity following Koch's molecular postulates; it allows creation of defined mycobacterial mutants either by allelic exchange or transposon mutagenesis, both of which were previously difficult or even unfeasible," researcher Vladimir Pelicic and colleagues wrote ("Efficient Allelic Exchange and...
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