Infectivity

Macrophage-Specific Loci Identified for Legionnaires' Bacterium

Published in TB and Outbreaks Week, March 16th, 1998

It appears that genetic loci are required for Legionella pneumophila to parasitize mammalian but not protozoan cells, according to a report from the University of Kentucky.

The report is not the first to identify differences in the bacterium which causes Legionnaires' disease.

"We hypothesize that L. pneumophila has evolved as a protozoan parasite in the environment but has acquired loci specific for intracellular replication within macrophages," Lian-Yong Gao and colleagues wrote ("Identification of Macrophage-Specific Infectivity Loci (mil) of Legionella pneumophila That are Not Required for Infectivity of Protozoa,"...

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Source: TB and Outbreaks Week (1998-03-16)

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