Virology

Large HDV Antigen Activates Gene Expression

Published in TB and Outbreaks Week, March 23rd, 1998

The large, but not the small, hepatitis delta antigen displays a novel activity - the ability to activate gene expression in trans, according to a report from the University of California.

Hepatitis delta virus (HDV) is an RNA virus that requires coinfection with hepatitis B virus (HBV) to complete its life cycle. The helper function supplied by HBV is limited to the provision of envelope proteins (hepatitis B surface antigens) for the completion of HDV assembly.

HDV RNA replication is independent of its HBV helper.

"The presence of HDV suppresses HBV replication in vivo," researchers Yu Wei and Don Ganem wrote...

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Source: TB and Outbreaks Week (1998-03-23)

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