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Opportunistic Infection (MAC)

Elevated IL-10 Involved in MAC Prevalence in AIDS

Published in TB and Outbreaks Week, March 23rd, 1998

Elevated monocyte/macrophage-derived interleukin-10 production may be a factor in the prevalence of Mycobacterium avium complex (MAC) infection of AIDS patients.

"Our findings clearly demonstrate abnormal IL-10 levels in HIV infected patients, with markedly higher serum levels and enhanced IL-10 release from peripheral blood mononuclear cells (PBMC) stimulated with MAC preparations and with the most pronounced abnormalities seen in patients with advanced disease," Fredrik Muller and colleagues wrote ("Enhanced Interleukin-10 Production in Response to Mycobacterium avium Products in Mononuclear Cells from Patients with HIV Infection," Journal of Infectious...

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