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Virology (TB

Human Monocytes Express M. tuberculosis Virulence

Published in TB and Outbreaks Week, March 23rd, 1998

Low-level infection of human monocytes with H37Rv, Mycobacterium bovis BCG, and H37Ra can serve as a model of M. tuberculosis virulence, according to a report from Cleveland, Ohio's Case Western Reserve University.

Researcher Richard F. Silver and colleagues found that the monocyte model correlates with the findings of traditional animal models.

"If this correlation is found with clinical isolates as well, the human monocyte model may provide a rapid and useful tool for clarification of the role of bacterial virulence in the epidemiology of outbreaks of tuberculosis," Silver et al. wrote ("Expression of Virulence of Mycobacterium...

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