"The Construction of a Model to Study Granuloma Formation in Mycobacterium tuberculosis Infection."

According to an abstract submitted by the authors to the International Conference on Emerging Infectious Diseases, held March 8-11, 1998, in Atlanta, Georgia, "The principal host defense against infection with Mycobacterium tuberculosis is the formation of a granuloma. This complex of activated macrophages, T lymphocytes, and fibroblasts is capable of preventing active disease by sequestering the invading organisms within this complex where they may remain latent for many years. To understand the process of granuloma formation and the granuloma's subsequent breakdown when host defenses are compromised, we developed an in vitro model. When THP-1 human monocytic cells, human...

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