Pathogenesis

Phagocytosis Mediated by M. tb LAM is Characterized

Published in TB and Outbreaks Week, July 27th, 1998

A mannose receptor-dependent phagocytosis mediated by Mycobacterium tuberculosis lipoarabinomannan has been characterized by researchers at the University of Iowa.

"This model will be useful in further characterization of the intracellular pathway taken by phagocytic particles coated with different lipoarabinomannan (LAM) types in macrophages following ingestion," Byoung K. Kang and Larry S. Schlesinger wrote ("Characterization of Mannose Receptor-Dependent Phagocytosis Mediated by Mycobacterium tuberculosis Lipoarabinomannan," Infection and Immunity, June 1998;66(6):2769-2777).

The macrophage mannose receptor (MR) along with complement...

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Source: TB and Outbreaks Week (1998-07-27)

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