HIV Vaccines
"Construction and Characterization of Recombinant BCG-Vectored Vaccine against HIV-1 Clade E Strain."
Published in TB and Outbreaks Week, September 21st, 1998
According to an abstract submitted by the authors to the 12th World AIDS Conference, held June 28 - July 3, 1998, in Geneva, Switzerland, "Objectives: To construct and characterize the recombinant Mycobacterium bovis BCG (rBCG) vector-based vaccine secreting the V3 principal neutralizing epitope of HIV-1 clade E strain. Methods: Synthetic DNAs encoding V3 sequences of clade E HIV-1 were inserted into a mycobacterial secretion vector and then introduced into BCG Tokyo substrain. The (alpha) antigen-V3 chimeric protein secretion from the rBCG was analyzed by Western blot assay using an antiserum of HIV clade E carrier. Antibody production was examined in guinea...
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