"CTL Response to Mycobacterium tuberculosis: Identification of an Immunogenic Epitope in the 19-kDa Lipoprotein."

According to the authors' abstract of an article published in Journal of Immunology, "The successful resolution of infection with Mycobacterium tuberculosis (M.tb) is believed to involve the induction of CTLs that are capable of killing cells harboring this pathogen, although little information is known about the MHC restriction or fine specificity of such CTLs, In this study, we used knowledge of the HLA-A*0201-binding motif and an immunofluorescence-based peptide-binding assay to screen for potential HLA-A*0201-binding epitopes contained in the 19-kDa lipoprotein of M.tb (M.tb19). CD8⁺ T cells derived from HLA-A*0201⁺ patients with active tuberculosis (TB)...

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