Published in TB and Outbreaks Week, October 26th, 1998
Since its introduction for clinical use as a tuberculosis vaccine and for immunotherapy against bladder cancer, the original bacillus Calmette-Guerin (BCG) vaccine strain has been subcultured many times and has been distributed to a large number of production centers throughout the world. As a consequence, several substrains of the original vaccine strain are now in circulation, and there is evidence that they vary in...
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