Diagnostics (TB)

Technique Predicts TB Diagnosis in 100 Percent of Tissue Samples

Published in TB and Outbreaks Week, October 26th, 1998

The traditional methods of tuberculosis detection, using sputum smear, often take weeks to produce results. The tests are also not appropriate for all cases.

Now, University of Arkansas investigators, using 60 fixed tissue specimens, showed that a technique using polymerase chain reaction (PCR) had a positive predictive value of 100 percent and a negative predictive value of over 88 percent.

They felt that PCR amplification of DNA in tissue would be useful to detect tuberculosis in patients in whom tissue diagnosis is needed, rather than detection of bacteria in bodily secretions.

Their study was published in the October 1998...

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Source: TB and Outbreaks Week (1998-10-26)

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