Immunology

GC to Anti-GC Steroids Important in TB Pathology

Published in TB and Outbreaks Week, December 21st, 1998

The ratio of GC to anti-GC steroids may be significant in the pathogenesis of tuberculosis, according to a report from Mexico.

Immunity to Mycobacterium tuberculosis requires a T helper 1 (Th1) cytokine balance accompanied by tumour necrosis factor-alpha (TNF-(alpha)), and activated macrophages. These facets of the immune response are sensitive to suppression by glucocorticoids (GC), which can reactivate and exacerbate tuberculosis.

Dehydroepiandrosterone (DHEA) and its derivative, 3(beta),17(beta) androstenediol (AED), are reported to have antiglucocorticoid properties in vivo.

In this study, R. Hernandez-Pando and...

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Source: TB and Outbreaks Week (1998-12-21)

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