"Response to Reactive Nitrogen Intermediates in Mycobacterium tuberculosis: Induction of the 16-kilodalton alpha-crystallin Homolog by Exposure to Nitric Oxide Donors."

According to the authors' abstract of an article published in Infection and Immunity, "In contrast to the apparent paucity of Mycobacterium tuberculosis response to reactive oxygen intermediates, this organism has evolved a specific response to nitric oxide challenge. Exposure of M. tuberculosis to NO donors induces the synthesis of a set of polypeptides that have been collectively termed Nox. In this work, the most prominent Nox polypeptide, Nox16, was identified by immunoblotting and by N-terminal sequencing as the alpha-crystallin-related, 16-kDa small heat shock protein, sHsp16. A panel of chemically diverse donors of nitric oxide, with the exception of nitroprusside,...

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