Vaccination

PstS-3 Protein is Candidate for TB Prevention

Published in TB and Outbreaks Week, February 8th, 1999

The PstS-3 protein is a promising new subunit vaccine candidate for the prevention of tuberculosis, according to a report from Belgium's Pasteur Institute of Brussels.

Using culture filtrate Ag-specific monoclonal antibodies generated from mycobacteria-infected H-2b haplotype mice, researcher A. Tanghe and colleagues have previously identified three genes in the Mycobacterium tuberculosis genome, encoding proteins homologous to the periplasmic ATP-binding cassette phosphate-binding receptor PstS of the phosphate-specific transport system of E. coli.

To define the potential vaccinal properties of these phosphate-binding proteins, female...

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Source: TB and Outbreaks Week (1999-02-08)

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