Immunology (TB)
"Pathophysiology of Antigen 85 in Patients With Active Tuberculosis: Antigen 85 Circulates as Complexes With Fibronectin and Immunoglobulin G."
Published in TB and Outbreaks Week, March 8th, 1999
According to the authors' abstract of an article published in Infection and Immunity, "Antigen 85 (Ag85) complex proteins are major secretory products of Mycobacterium tuberculosis and induce strong cellular and humoral immune responses in infected experimental animals and human beings. We have previously shown that nanogram doses of these 30- to 32-kDa fibronectin-binding proteins inhibit local expression of delayed hypersensitivity by a T-cell fibronectin-dependent mechanism. Circulating levels of Ag85 might be expected to be elevated in patients with active tuberculosis and possibly to play a role in systemic anergy in these patients. To test this hypothesis, Ag85 was measured...
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