"Isoniazid Accumulation in Mycobacterium smegmatis Is Modulated by Proton Motive Force-driven and ATP-dependent Extrusion Systems."

According to the authors' abstract of an article published in Biochemical and Biophysical Research Communications, "Resistance to isoniazid (INH), a frontline, antituberculosis drug, presents a major problem in the chemotherapy of tuberculosis. Although several targets of INH have been identified, the mechanism of INH resistance remains incompletely understood. This report demonstrates that INH accumulation in Mycobacterium smegmatis is enhanced both upon addition of both a proton motive force (pmf) uncoupler, carbonyl-cyanide m-chlorophenylhydrazone (CCCP), and upon addition of ortho-vanadate, an inhibitor of ATP-dependent efflux pumps. Both the Delta psi and Delta pH components...

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